International Conference on Polycystic Ovarian Syndrome & Infertility September 21-22, 2020 Tokyo, Japan

Track 1- Polycystic Ovary Syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine syndrome with variable prevalence, affecting about one in every 17 women worldwide. The diagnosis of polycystic ovary syndrome requires as a minimum two of the following criteria: anovulation, clinical, biochemical evidence of hyperandrogenism and morphology of polycystic ovaries. Women with PCOS appear to have a higher risk of developing metabolic syndromes, hypertension and cardiovascular disorders.

Track 2- Fertility and Infertility – Women

Fertility is the capacity to produce posterity and conceive. Human fertility depends upon various elements .A woman’s most fertile time is during ovulation. Ovulation occurs within 11th to 21st day of a woman’s cycle.  Infertility is a condition which is found in both men and women, and both of them are affected almost equally. Infertility in men and lady can likewise be treated with ARTs.

Track 3- Women’s Health Related Issues

Women's health has been a long concern but nowadays it has reached an extreme point of concern. Normally women and men share similar health challenges the only difference is that the health of women deserves particular attention. There are biological processes such as childbirth and pregnancy that carry health risks and are the principal cause of death in young women between 15 and 19 years old in developing countries. The leading cause of death among women of reproductive age is HIV/AIDS which is due to biological factors and limitation of women’s knowledge about HIV and unsafe sex. Lack of contraception results in unwanted pregnancies, unsafe abortions, sexually transmitted infections, etc.

Track 4- Gynecology

Gynecology and Obstetrics is the medical specialty that includes the two subspecialties of obstetrics and gynecology that is covering the health of the female reproductive systems (i.e.,vagina) and ovaries. Gynecology is the sub branch of medicine dealing with the administration of health care to women, especially the analysis and treatment of disorders affecting the women’s reproductive organs and it also deals with the study of diseases of the female reproductive surgery, including and issues related to reproductive hormones.

Track 5- Gynecological Endocrine Disorders in PCOS

Polycystic ovary syndrome (PCOS) is a typical reason of ovulatory dysfunction. This disorder involves anovulation dysfunction and androgen excess of unclear etiology. Estrogen levels are raised, increasing risk of endometrial hyperplasia and, eventually, endometrial cancer. Androgen levels are regularly raised, increasing the risk of metabolic syndrome and causing hirsutism. Hyperinsulinemia occurs due to insulin resistance may be present and may contribute to increased ovarian production of androgens. The risk of cardiovascular disorders, including hypertension and hyperlipidemia. Polycystic ovary syndrome (PCOS) is a typical reason of ovulatory dysfunction. This disorder involves anovulation dysfunction and androgen excess of unclear etiology. Estrogen levels are raised, increasing risk of endometrial hyperplasia and, eventually, endometrial cancer. Androgen levels are regularly raised, growing the risk of metabolic syndrome and causing hirsutism.

Track 6- Pregnancy Hypertension

Hypertension is the major medical problem comes upon during pregnancy, complicating up to 15% of pregnancies. Hypertensive disorders during pregnancy can be classified into 4 types such as Chronic Hypertension, Gestational Hypertension, Preeclampsia and Eclampsia. Hypertensive pregnancy disorders represent the important complications of pregnancy and contribute significantly to maternal , perinatal morbidity and mortality. The main aim of treatment is to prevent significant cerebrovascular and cardiovascular events in the mother, without compromising fetal well-being.

Track 7- Reproductive Endocrinology and infertility

Reproductive Endocrinology and Infertility is belongs to the Department of Obstetrics and Gynecology. The research area is related to human reproduction including female and male infertility, assisted reproductive technologies. Those include reproductive surgery, endometriosis, uterine fibroids, polycystic ovary syndrome, developmental problems, and issues related to reproductive hormones. In vitro fertilization is also type of assisted reproductive technology which is used in infertility treatment.

Track 8- Complications during pregnancy

Women face lots of health problems during pregnancy. These problems can involve the mother's health, the fetus's health, or both. Even women who were healthy before getting pregnant can face complications. These difficulties may make the Complications during pregnancy.

Some common complications of pregnancy listed the following.

• High blood pressure
• Gestational diabetes
• Miscarriage
• sexually transmitted infections

Track 9- Immunological Approaches of fertility

Immune infertility has become a severe health issue involving 2 in 10 women under normal conditions; moreover, a woman with the polycystic ovarian syndrome has become very frequent. Semen that is known as the composite fluid which contains sperm, cellular vesicles, and other cell components, this semen could be a reason for sensitization of female genital tract. Iso-immunization is also associated with infertility. Numerous specific components of the regenerative system which do not represent in other body systems those many of are immunogenic efforts. The major advantage involved in the immunological approach of fertility is very effective or potential for women who are infrequent administration by a specialist's trained people who could deliver antifertility services.

Track 10- PCOS Advanced Research

Effective study about the PCOS gives that it is caused by abnormal functioning of hormones and by the metabolic endocrinological disorder. There are more research works are process on the investigation to find the exact a rise of the disorder and the partial way to sustain the further action worsened by the PCOS. The recent research work on plant product called Resveratrol- product obtained from the plant synthesis. Resveratrol has a property of Anti-oxidant most of the plants contain a type of phenol called phytoalenin  which obtained from plant tissues in response to invading fungus and stress and it also had a clinical feature of inflammatory properties it involves in the reduction of coronary heart diseases and it shows an effective work of fighting against cancer. Resveratrol drug is administrated into the systemic circulation of the women fighting with PCOS that may show an effective work against the hormonal imbalances. Evaluation can be done by taking the blood sample of the patient after 3 months of treatment for the determination of testosterone levels and other androgen hormone levels in the blood that which shows the development/ implementation of the syndrome. This defines the alteration of the implement. Taking natural diet like almonds, milk, and veggies can help to improve fertility and makes normal hormonal function.

• Advanced works on PCOS and Mental Health
• Metformin and Lower Risk factors for Miscarriage
• Comparative studies of Allopathic and Homeopathic Medications
• Natural remedies to cure of Ovarian Cysts
• Advanced treatments to Improve Fertility

Track 11- Research in Clinical Obstetrics and Gynecology

Obstetrics is generally known as the branch that which deals with the study of pregnancy, childbirth and the postpartum period. Based on the consequent changes in the surgical methods it is combined with the Gynaecological department and it is fairly known as Obstetrics and Gynaecology as a surgical field. This field of obstetrics is correlated with gynaecological conditions like Polycystic ovarian syndrome (PCOS) which has a vast and varied relation with the women bearing pregnancy this PCOS consequence has an utmost effect on reproductive women. Women with PCOS can experience Gestational Diabetes, Preeclampsia. This leads to the maternal mortality the main causes of the maternal mortality are maternal bleeding maternal sepsis. There is no difference between symptoms and complication /Discomfort of pregnancy.

Track 12- Diagnosis and Treatment of Polycystic Ovary Syndrome

Polycystic ovary syndrome is the common endocrinopathy among reproductive-aged females in the all over the world, affecting approximately 6% of female patients. The pathophysiology of the disease is complex and there is no single defect from which it is known to result, it is hypothesized that insulin resistance is a key factors from asymptomatic to having multiple gynecologic, dermatologic, or metabolic manifestations. Advices from the Endocrine Society mentioned using the Rotterdam criteria for diagnosis, which mandate the presence of two of the following three findings—hyperandrogenism, ovulatory dysfunction, and polycystic ovaries and plus the exclusion of other diagnoses that could result in ovulatory dysfunction.

Track 13- PCOS & Stem Cell treatment

Stem cells are homogeneous cells which are capable of self-renewal (reproducing themselves) and distinguishing into different types of cells. The two main properties of stem cells are self-renewal and potency which allow them to differentiate into any kind of cells. As of late in 2004, two investigations demonstrated that ovaries do contain stem cells which form oocytes in grown-ups and that can be cultured in vitro into develop ones. Another investigation gave novel confirmation of endometrial recovery by stem cells in women who got bone marrow transplants. This finding has potential for the utilization in treatment of uterine disorders and has a potential for the use in treatment of uterine disorders. It also supports a new theory for the cause of endometriosis, which is a condition in which cells similar to those in the endometrium grows outside of it.

Track 14- Fertility Surgery and IVF Treatment

In vitro fertilization is a type of assisted reproductive technology which is used in infertility treatment or genetic problems and assist with the conception of a child. In IVF an egg is fertilized with sperm outside the body in a liquid medium in a specialized lab. The zygote goes through embryo culture for a period of 2–6 days, and then the specialist re-implants the embryos back into the woman’s uterus. This process intends to initiate a successful pregnancy.

Track 15- Effects of Drugs on Pregnancy

Pregnancy is a special physiological condition where treatment of drug is an important concern as the physiology of pregnancy affects the pharmacokinetics of treatment used some medications can reach the fetus and harms them. Treatment for pregnant woman cannot be totally avoided since some may have chronic pathological situations that require continuous or interrupted treatment like asthma, epilepsy and hypertension.  New medical environments can develop, and old ones get worsen during pregnancy requiring drug therapy, which becomes a major problem for child bearing women to take medication whether prescription, over-the counter, or herbal medication.

Track 16- Epidemiology and Pathophysiology

Epidemiology

Epidemiology is the study and analysis of the distribution and factors of health and disease conditions in defined populations. It is in the basis of public health, shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare. Epidemiology has assisted to develop procedures which are used in clinical research, public health studies, and, to a lesser extent, basic research in the biological sciences.

Pathophysiology

Pathophysiology is a part of pathology with physiology. It is a deranged function in an individual or an organ due to a disease. Pathology depicts conditions ordinarily saw during an infection state, while physiology is the natural order that characterizes procedures working inside a organism. Pathology clarifies the undesired condition, though pathophysiology looks to clarify the useful changes that are happening inside a person because of an illness or pathologic state. Pathophysiology can likewise mean the utilitarian changes related with damage. Another definition is the useful changes that go with a specific illness.

Track 17- Current trends in the treatment of PCOS System

Metabolic syndrome is most common in patients with polycystic ovary syndrome when it is compared with the overall population, and patients with polycystic ovary syndrome are four times more likely than the general population to develop type 2 diabetes mellitus.

Treatment of PCOS is individualized based on the patient's presentation and desire for pregnancy. For patients who are having overweight for them weight loss is recommended. Clomiphene and letrozole are first-line medications for infertility. Metformin is the first-line medication for metabolic manifestations, such as hyperglycemia. Hormonal contraceptives are the best treatment for irregular menses and dermatologic manifestations.

Importance & Scope:

PCOS 2020 deals with Polycystic and Ovarian Syndrome knowledge and characteristics, Screening, Detecting and Diagnosing PCOS, Fertility issues, Treatment, prevention and medicine. The correct reason for PCOS is obscure. For the most part, it is a hormonal issue normal among ladies of regenerative age. Ladies with PCOS may have inconsistent or drawn out menstrual periods or overabundance male hormone (androgen) levels. Awareness about the risks, symptoms and treatment is very important. Introduction of new techniques in the field of medicine as well as diagnosis is going on worldwide. PCOS 2020 give a stage to sharing of data about the PCOS treatment methods and recently created strategies for the same and in addition give stage about the on-going examines on it. This occasion incorporates incite keynote introductions, oral talks, blurb introductions and displays.

Major PCOS Associations around the Globe

• Androgen Excess and Polycystic Ovary Syndrome(AE-PCOS)Society
• Endocrine Society (USA)      
• American Dietetic Association
• American Society Reproductive Medicine
• American Association Of Clinical Endocrinologists
• The European Society of Human Reproduction and Embryology
• Australian Breastfeeding  Association
• Polycystic Ovary Syndrome Association of Australia
• The Association of UK Dietitians
• Canadian Fertility and Andragogy Society Polycystic Ovarian Syndrome Association
• Association for Fertility and Reproductive Health, Nigeria

     Top Societies of PCOS in the World

• Androgen Excess and Polycystic Ovary Syndrome Society 
• American diabetes association
• Endocrine society of Australia

Top Universities of PCOS in World

• University of Utah
• University of Athens
• Harvard University
• Monash University
• University of Bologna
• University of Adelaide
• Virginia Commonwealth University
• University of Sao Paulo
• University of Palermo
• Northwestern University
• Hacettepe University
• University of Chicago
• University of Leeds
• University of Michigan
• University of California San Francisco
• University College London
• Goteborg University
• University of Pennsylvania
• Peking University
• Yeshiva University
• Yale University
• McGill University

      Top Universities in Asia

• University of Hong Kong
• Tel Aviv University
• Hebrew University of Jerusalem
• National University of Singapore
• Chinese University Hong Kong
• Peking University
• Seoul National University
• Beijing Normal University
• Nanyang Technological University
• National University of Singapore
• Tsinghua University
• Peking University
• Nanyang Technological University
• Chinese University of Hongkong
• University of Tokyo
• Seoul National University
• Kyoto University

     Companies associated with PCOS in Global

•      Sanofi
•      Novartis AG
•      Teva Pharmaceutical Industries Limited 
•      Addex Therapeutics Ltd. 
•       BIOCAD
•       Merck KGaA
•       AstraZeneca plc.
•      Bristol Myers Squibb Co. 
•       Ferring Pharmaceuticals, Inc.
•       Crinetics Pharmaceuticals, Inc

Statistics which shows Market growth in importance of research of PCOS

PCOS is the commonest cause of an ovulatory infertility in women. Women may also suffer from cancer of the womb, obesity, cardiovascular disease, diabetes and hirsutism. It affects 6-20% of women in the population and the current expected annual costs of diagnosing and treating infertility secondary to PCOS in the UK range from £15million to £20 million whereas the health economic effect of PCOS in the USA effects 10-20% and has been estimated as ranging from $93 million to $1.77 billion. Although important progress has been made in our understanding of PCOS, there are still challenges in unraveling its difficulty. The analysis of PCOS is based on a combination of clinical, ultrasound and biochemical features, none of which on its own is diagnostic single unifying mechanism has yet to be found which explains PCOS, and accurate prediction of response to treatment for obesity, infertility.

 Worldwide Data evaluations that the global PCOS therapeutics market was valued at $656m in 2010, and is expected to grow at a static Compound Annual Growth Rate (CAGR) of 2.6% over the next eight years, to reach $804m by 2018. Annualized seven key markets (US, France, Germany, Italy, Spain, UK and Japan) Polycystic Ovarian Syndrome Therapeutics market revenues data from 2005 to 2009, forecast for eight years to 2018.according to PCOS Therapeutics market revenue, the market size from 2005-2010 in Italy is 33, USA is 26, Spain is 35,in France 28,whereas in Germany is 31,whereas in UK is37  whereas from 202-2018 in Italy is 34,in us is 27,spain is36, in France is 29,in Germany is 32, whereas in UK is  38. The Polycystic Ovarian Syndrome Market Will Start Growing From 2013 Due To the Increase in Disease Prevalence and Prescription Rates and Will Rise to $702m In 2019. The global market for PCOS drugs is on an upward swing given the increasing number of cases of patients inflicted with the disease. The global polycystic ovary syndrome drugs market revenue is estimated to reach US$ 1,154.8 MN by 2024, expanding at a CAGR of 4.6% during the forecast period (2016–2024).

With the successful completion of 2018 Conference World Congress on Polycystic Ovarian Syndrome and Fertility conducted by the Conference Series which was held during December 17-18, 2018 in Abu Dhabi, UAE. This offered great opportunities to the researchers working on this are to network, share ideas and perceive new scientific works. Mass and active participation was received from the Editorial Board Members of Journals as well as from the Researchers, Gynaecologists, and Doctors, endocrinologists, students and many more from all across the globe.

The conference was initiated with the Honourable presence of the Keynote forum. The following list below includes:

• “Overview of breast reconstruction options and latest advances and controversies”, by Omar Tillo, Bedford Hospital NHS Trust, United Kingdom
• “Disorders of puberty and Polycystic ovary syndrome (PCOS)”, by Dalida Omar Badla, Danat Al Emarat Hospital for Woman &Children, UAE
•  “Past present and future of medicinal practice and breast cancer prevention”, by Zoella Vlamaki, NHS Trust, UK
• For More details visit: https://pcos.insightconferences.com/
• Book mark your calendars; we are hoping to see you soon!
• Let us meet again @ PCOS 2020 Conference